[Doctor's Column] Maunzaro, Why Is He Getting More Attention Than Wigobi?

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Studying the outer and inner layers of the skin

Director Kim Tae-hee of Sunae May Pure Clinic no see.

There is a question I hear most often during obesity treatment consultations recently.

"I heard Maunzaro is better than Wigobi?"

Aren't both of them diet injections?

Both drugs are injectables used for weight loss, but there are significant differences in their mechanisms of action.

Today, we will discuss the most 주목받는 obesity treatment drug recently. Mounjaro® (tirzepatide) Let's examine what kind of medicine it is and how it differs from Wigobi based on evidence.

What kind of medicine is Maunjaro?

The ingredient name of Maunzaro is Tirzepatide no see.

Most existing obesity treatments GLP-1 receptor It was a method of stimulating.

On the other hand, Maunzaro

• GLP-1

• GIP

Activating two hormone receptors simultaneously Dual GIP/GLP-1 receptor agonist is. For this reason, commonly Dual incretin or Twincretin It is also called...

✔ Loss of appetite

✔ Reduced gastric emptying rate

✔ Increased satiety

✔ Blood sugar control

Wigobi (semaglutide) It is a drug that selectively activates only this GLP-1 receptor.

GIP It is also the incretin hormone secreted after a meal.

Although it did not receive much attention in the past, recent research When acting in combination with GLP-1

✔ Appetite control

✔ Energy Metabolism

✔ Insulin secretion

✔ Adipose tissue metabolism

It has been revealed that it can show a synergistic effect in the back.

Maunzaro is this The first obesity treatment that activates two hormones simultaneously no see.

Why is the weight loss effect greater?

The most famous study SURMOUNT-1 no see.

Non-diabetic obese patients targeting 72 weeks As a result of treatment during that time,

• Average weight loss of about 15–21%

• At the highest dose, more than half lose more than 20% of their body weight I did.

This The greatest weight loss effect among obesity treatment drugs announced to date It is evaluated as one of the

A study directly comparing it with Wigobi has also been published.

Announced in 2025 SURMOUNT-5 In the study

Direct comparison of Maunzaro and Wigobi I did.

72 weeks later

• Maunzaro: Average weight loss 20.2%

• Wigobi: Average weight loss 13.7%

Lo Maunzaro showed greater weight loss.

also Waist circumference reduction as well It appeared more significantly in the Maunzaro group.

But does that mean it is a better medicine for everyone?

That is not necessarily the case.

The selection of obesity treatment drugs is

• BMI

• Comorbidities

• Whether or not to have diabetes

• Previous drug use experience

• Gastrointestinal side effects

• lifestyle habits

You must make a decision by comprehensively considering the above factors.

Therefore, Maunzaro is not suitable for everyone simply because it is "more effective." It is important to establish a treatment strategy tailored to the individual after sufficient consultation with medical professionals.

📢  Launched by Maypure, Maunzaro!

• Consultation fee free

• At Sunae May Pure Clinic, personalized prescriptions are available after consultation with medical staff specializing in family medicine and internal medicine.

📚 References (Searchable on PubMed / Google Scholar)

1. Jastreboff AM, et al. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 2022;387:205-216. (SURMOUNT-1)

2. Aronne LJ, et al. Tirzepatide as Compared with Semaglutide for the Treatment of Obesity. N Engl J Med. 2025. (SURMOUNT-5)

3. Frias JP, et al. Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes. N Engl J Med. 2021.

4. Wilding JPH, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021.

[Mandatory Notices for Compliance with Medical Act]

※ All dermatological procedures may result in side effects, ranging from minor to major, such as erythema, swelling, burns, inflammation, and cheek hollowing, depending on an individual's skin condition and characteristics. This post is written for the purpose of providing medical information and does not guarantee 100% of the results of any specific procedure. Please be sure to have a thorough in-person consultation with experienced medical professionals before the procedure.