[Doctor's Column] Why Maunzaro is More Effective for Weight Loss Than Wigobi

[닥터칼럼] 마운자로가 위고비보다 체중감량 효과가 더 큰 이유

The reason why Maunzaro is more effective for weight loss than Wigobi

What will change if GIP is added?

hello.

Studying the outer and inner layers of the skin Director Kim Tae-hee of Sunae May Pure Clinic no see.

In the previous post comparing Maunzaro and Wigobi

Maunzaro showed a greater weight loss effect on average. We have introduced the research results.

In that case, many people are curious.

"Why on earth does it fall out more easily?"

Today is the key point

GIP (Glucose-dependent Insulinotropic Polypeptide)

Let's find out about it.

The biggest difference between Wigobi and Maunzaro

Wigobi Is

✔ Activation of only GLP-1 receptors do.

the other side Maunzaro Is

✔ GLP-1

✔ GIP

It activates two hormones simultaneously.

So, Maunzaro

Dual Incretin Therapy or Twincretin It is called.

What kind of hormone is GIP originally?

GIP is also secreted in the small intestine when you eat. Incretin hormone no see.

In the past, it was known as a hormone involved only in blood sugar regulation, but

Recent studies have revealed that it plays a very important role in obesity treatment.

What will GIP do?

Recent studies report that GIP is involved in the following actions.

① Appetite control

It may act on the hypothalamus in conjunction with GLP-1 to suppress appetite more effectively.

② Energy Metabolism

Studies are being published suggesting that it can affect not only food intake but also energy consumption. Although the full mechanisms in humans have not yet been fully elucidated, positive results are being reported in animal experiments and clinical studies.

③ Fat Metabolism Function

Recent studies suggest that GIP may also be involved in the function and metabolism of fat cells. Rather than simply "burning fat" It can affect the metabolic regulation of adipose tissue. Understanding it that way is more in line with the current basis.

④ Possibility of enhancing the effects of GLP-1

This is currently the most 주목받는 (highly anticipated) aspect. Compared to GLP-1 alone

If you activate GIP together

Increased satiety
loss of appetite
Blood sugar control

The key point of current obesity treatment research is that the effect can be even greater.

So, what is the actual weight loss effect?

STEP-1 (Wigobi large-scale clinical trial)

Wigobi(S emaglutide), 68 weeks of use, average 14.9% weight loss

SURMOUNT-1 (Maunzaro large-scale clinical trial)

Maunzaro (Tirzepatide), 72 weeks of use, average 15~21% weight loss

At maximum capacity More than half of the patients lost 20% or more.

SURMOUNT-5 Direct Comparison (Large-scale clinical trial comparing Wigobi vs. Maunzaro)

A study published in 2025 directly compared the two drugs.

	Maunzaro	Wigobi
Average weight loss	20.2% decrease	13.7% decrease
Waist circumference reduction	18.4cm decrease	13.0cm decrease

In other words, large-scale studies published to date have shown that Maunzaro has, on average, a greater weight loss effect.

Then, is GIP everything?

Not yet.

Researchers are currently continuing to investigate exactly what mechanisms create these differences.

So far

Synergistic effect of GLP-1 and GIP to increase weight loss

It is thought to play an important role.

However, GIP alone is insufficient to explain it, and it is most accurate to understand it as a complex mechanism working together.

The important thing is

Every medicine has its pros and cons.

Maunzaro is not necessarily more suitable for everyone.

The following factors must be considered together.

✔ BMI

✔ Diabetes status

✔ Target weight

✔ Previous medication use experience

✔ Gastrointestinal diseases

✔ Risk of side effects

Therefore, it is important to select the treatment suitable for the individual through sufficient consultation with medical staff.

📚 References (Searchable on PubMed / Google Scholar)

Jastreboff AM, et al. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 2022;387:205-216. (SURMOUNT-1)
Aronne LJ, et al. Tirzepatide as Compared with Semaglutide for the Treatment of Obesity. N Engl J Med. 2025. (SURMOUNT-5)
Frias JP, et al. Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes. N Engl J Med. 2021;385:503-515. (SURPASS-2)
Wilding JPH, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384:989-1002. (STEP-1)
Holst JJ, Rosenkilde MM. GIP as a Therapeutic Target in Diabetes and Obesity: Insight From Incretin Co-agonists. Nat Rev Endocrinol. 2020.
Samms RJ, et al. GIP receptor agonism mediates weight loss and improves metabolic control when combined with GLP-1 receptor agonism. Cell Metabolism. 2021.

[Mandatory Notices for Compliance with Medical Act]

※ All dermatological procedures may result in side effects, ranging from minor to major, such as erythema, swelling, burns, inflammation, and cheek hollowing, depending on an individual's skin condition and characteristics. This post is written for the purpose of providing medical information and does not guarantee 100% of the results of any specific procedure. Please be sure to have a thorough in-person consultation with experienced medical professionals before the procedure.

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<The Maunzaro Series Recommended for Reading Together>

👉Maunzaro vs. Wigovi

https://blog.naver.com/dr_insideout/224336141708

👉 Why Maunzaro is more effective for weight loss than Wigobi

https://blog.naver.com/dr_insideout/224336167993

Can people with a normal weight be prescribed Maunzaro?

https://blog.naver.com/dr_insideout/224336200371

👉Comprehensive Summary of Maunzaro Side Effects

https://blog.naver.com/dr_insideout/224336242086

Will I lose muscle if I get hit by Maunzaro?

https://blog.naver.com/dr_insideout/224336865164